Unless you use Fedora Atomic distros, then you do need to reboot.

This page says it works, but it also might be a pain to setup.

Usually is limited by headset/controllers support. Take a look at Linux VR Adventures Wiki for compatibility.

It might be worth also teaching your friend how to:

• install games via Lutris (if they downloaded the Sims while sailing the high seas)
• to change Proton/Wine versions (for compatibility, if they play older titles)
• how to install libraries through Winetricks/Protontricks (again for older titles requiring abandoned libraries like playing .wmv files in-game)
• how to mod the Sims and how to run .exe tools inaide Wine/Proton prefixes (such as Anadius’ tool for Sims 4)