AlphaFold does a couple of things. It’s capability in predicting how a single protein will be folded tends to be quite nice, but organisms often rely on complex interactions between proteins. It has a feature to calculate the folding of two or more proteins with each other, which is incredibly important to understand more complex interactions in various processes in the human body, as well as drug interactions.

It is also easier to create a database of folding for all normal proteins in the human body. Any change in your DNA, which is somewhat more common than people think, can modify your proteins to one that has not been seen before, since many proteins can have chunks that don’t do anything but act as filler. Except, when those changes affect a bit that doesn’t act as filler or make the filler suddenly interact with other proteins or structures, like making the protein fold entirely differently or become hydrophobic where it shouldn’t be, then you’re in trouble.

These modified proteins need to be analyzed as well and when their primary function in your body is to interact with other proteins, then this multimer functionality is critical. And that certainly needs much more research, as it is very, very far from perfect.

You hit on a point there I really missed out on in my comment. Sims 2 had that perfect unique character of being weird and endearing at every corner. I feel like Sims 3 frankly was losing it already and by the times of Sims 4 it had just felt entirely corporate already.

The games used to have a very delightful degree of strangeness that was only aided in by the eccentric but utterly iconic music it ran with. I was rather young when I played Sims 1, so Sims 2 is my nostalgia home turf, but I love both of their soundtracks. Mark Mothersbaugh’s music in particular just puts me into an entire space of it’s own when I hear it. Don’t think there is music that more embodies the lightness of existence than that.

I miss the times when somehow they juggled making me feel like my Sims achievements are somewhat hard won and meaningful with the silliness of having my Sim dream of nothing but grilled cheese and living next door to plant people and aliens. Incarnations of Strangerville after Sims 2 just never quite hit the note that that game managed to nail.

I can pitch in that for me at least, Sims 4 was a large improvement in terms of the UI and UX in regards to both CAS and Build Mode. It has a lot of small stuff that makes the experience much more accessible for me, personally.

It also comes with a visual style that I myself quite prefer, but this is controversial itself.

I still find myself getting bored of actual play in Sims 4 rather quickly, since things just don’t feel like they require much investment at all anymore. Being a perfect all-rounder of a Sim is utterly trivial in Sims 4 while Sims 3 and 2 back then made me feel like I had to work for it quite a bit. It may just be me being more capable, who knows.

I’ll say, I can’t say the business model of any of these games has appealed to me. I have purchased the base games for all the titles in the series, but have chosen to experience the DLC in a more budget friendly way. Yar har, et al.

It’s a pity we’ve lost a lot of things that were great that they just didn’t feel like building on. The neighbourhoods in Sims 4 feel terrible and I wish we’d have found some way to make Create a Style from Sims 3 work without bogging down the performance quite as much. At the time when Sims 4 rolled around, I was also happy to swap as my PC at the time just couldn’t handle the game running smoothly anymore, either.

Sims 4 is not really a development that will do the series good in the long run, but it can’t be denied that it has some really great changes that for me at least make building and decorating buildings feel much more fun.

In no sense did I say that other people’s dislike for their games is a problem. I take no offense to that. I myself am literally of the opinion that the newer AC games are hard to enjoy and insulting to the players time.

Nonetheless, I can acknowledge that it’s a source of comfort for some, even when I fail to enjoy it. Making them feel bad about it just isn’t OK.

I’m sorry, but “Really? Ubisoft though?” is not just rubbishing Ubisofts practices. It’s condescending to OP.

The fact that just because I criticized your choice of words makes you assume that it’s in defense of my own tastes is unreasonable too. Is there not a chance someone might sympathise with someone without sitting in the same exact boat as them?

Point is, many people would feel bad about being approached the way you did and it is not exactly unreasonable to think that they would.

There’s so much attempted shaming in these comments. People like some of their games and some like them a lot. Even if you don’t feel like they’re the best, Original and Odyssey still carry the attachment people have for Assassin’s Creed and Anno 1800 has no real direct comparable alternatives.

Stop trying to make people feel bad for just wanting to enjoy something they like when they are the victim of these companies trying to make their life harder. The fact that Ubisoft treats their customers like trash isn’t something to rub in someone’s face, it’s too bad that some people’s hobbies are locked behind something like that.