Possibly? Though I wouldn’t recommend it. I tried that with xfce once, and it technically worked, but tiling window manager and desktop environments tend to have different aims. A desktop environment like plasma will have everything bundled together and playing well as a whole, while a window manager like i3 will be barebones and expect you to pick out the pieces yourself. DE’s are much more beginner friendly, while WM’s are great if you want to get as much customization as possible. Which will better suit you depends on your needs.

Distro isn’t important for tiling, just the window manager. I’d start with i3 personally, it’s been around a long time, which means the documentation is fairly plentiful.

herbstluftwm or something, idk I use Sway