I think I understood overall how this DeNuvo bypass works, but one thing I’m not sure about yet is the following. If I disable the security layers, play the game, then enable again those security layers, would I be as secure as I was before? Or some hidden malware might have taken the opportunity to permanently infect my PC beyond recovery?


It’s absolutely possible. That’s why reputable sites like FitGirl reccomend you disable the security, restart your computer, play the game, then re-enable the security, and restart again.
Don’t run other shit or browse the web, minimize what you’re doing and running while your security is weakened to the bare minimum. Play the game and that’s it, then put things back to “safe”.
As with any crack or bypass software, you shouldn’t run it if you don’t trust the source. These hypervisor bypasses are really for special cases where you absolutely can’t wait for a traditional crack.
I’d argue personally that you can always just wait.
Now the actual likelyhood of anything taking advantage and being able to deeply persist once you turn the security settings back on? Can’t really say. I would assume the chance is unlikely, but that’s not based off of fucking anything substantial.