Only if the CPU and motherboard support quad-channel memory, which is usually only found on High End Desktop platforms. Even the high end consumer CPUs you might consider for a new build - like a Ryzen 9 9950X3D or Intel Core Ultra 9 285K - are limited to dual channel.
In Ryzen’s case, the officially supported memory bandwidth is reduced when you populate 4 modules. For the aforementioned 9950X3D, you’re guaranteed support for 5600Mhz with two modules and that drops down to 3600Mhz with four. Whether or not you actually have issues will depend on the properties of the unique CPU you end up with / silicon lottery.
Only if the CPU and motherboard support quad-channel memory, which is usually only found on High End Desktop platforms. Even the high end consumer CPUs you might consider for a new build - like a Ryzen 9 9950X3D or Intel Core Ultra 9 285K - are limited to dual channel.
In Ryzen’s case, the officially supported memory bandwidth is reduced when you populate 4 modules. For the aforementioned 9950X3D, you’re guaranteed support for 5600Mhz with two modules and that drops down to 3600Mhz with four. Whether or not you actually have issues will depend on the properties of the unique CPU you end up with / silicon lottery.