Genetics barely explains 1% of Alzheimer. The problem with Alzheimer dementia, FTD, is that they are likely many causes with a common outcome.
Some AD is caused by diabetes.
Some AD is caused by trisonomy 21, Down’s syndrome.
Some AD is caused by venous blood restriction.
In later life, the brain accumulates a lot of reactive oxygen species that old mitochondria can’t handle, the result of that oxidation is elevated DNA damage. Some people have efficient DNA repair, some do not. Why? Efficient DNA repair can promote cancer.
In the broad picture of humans, those that avoid cancer are more likely to get AD, an vice versa.
Genetics barely explains 1% of Alzheimer. The problem with Alzheimer dementia, FTD, is that they are likely many causes with a common outcome.
Some AD is caused by diabetes. Some AD is caused by trisonomy 21, Down’s syndrome. Some AD is caused by venous blood restriction.
In later life, the brain accumulates a lot of reactive oxygen species that old mitochondria can’t handle, the result of that oxidation is elevated DNA damage. Some people have efficient DNA repair, some do not. Why? Efficient DNA repair can promote cancer.
In the broad picture of humans, those that avoid cancer are more likely to get AD, an vice versa.