Nicotine isn’t really easy to take in. It causes massive stomach upset, plus it affects the mucus membranes. You would barf and feel like total shit trying to drink it. I don’t know all the scientific specifics, but yeah. I do know though that there is a liquor made in part with tobacco. Dunno how that works, but I’m sure the specific methods of fermentation and proofing must kill whatever would affect you in such a way.