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Cake day: June 12th, 2023

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  • It’s not so much about time (although I have played a couple of things that would take a ridiculously long time to save or load), it’s about the number of chances to make a mistake. If you only save ten values, it’s really easy for a programmer to verify that they’ve got everything right, but if they save ten million, there are a million times more opportunities for mistakes to sneak in and it’s much harder to notice each mistake, let alone fix it.

    Fallout 4 is a bit of an odd duck here as the save format for the BGS games is basically just another ESM file, so reuses all the same serialisation and deserialisation mechanisms. Most games don’t have multiple places the game data can come from and a way to combine them as they’ve not got an engine designed with this kind of modding in mind, so there’s nothing to reuse in this way for saves. Given the general standards of engineering from that studio, if they didn’t have this as a core feature of their custom engine for nearly three decades, and instead had to come up with something from scratch, they’d absolutely mess it up or have to simplify the saving system.










  • OED:

    1. totally or partially resistant to a particular infectious disease or pathogen.
    2. protected or exempt, especially from an obligation or the effects of something.

    Merriam Webster

    1. : not susceptible or responsive

      especially: having a high degree of resistance to a disease

    2. a: produced by, involved in, or concerned with immunity or an immune response

      b: having or producing antibodies or lymphocytes capable of reacting with a specific antigen

    3. a: marked by protection

      b: free, exempt

    So unless you pretend that MW’s 2b sense is the only valid one, the immunity is immunity.

    If you have a sample of HIV at 37°C in blood, but with all the immune cells removed, it’ll still all become inert after around a week simply due to chemical reactions with other components of blood etc… It’s pretty comparable to a population of animals - if you take away their ability to reproduce, they’ll die of old age when left for long enough even if you’re not actively killing them.

    Edit: fat-fingered the save button while previewing the formatting


    • this is a shitpost community, not a biotech publication, so immune here means the dictionary definition, not any domain-specific technical jargon, otherwise people can’t make shitposts about diplomatic immunity
    • lacking the receptor that HIV uses to hijack the regular immune response in order to reproduce means the regular immune response destroys it
    • even in a normal person, after exposure, a lot of HIV gets destroyed by other parts of the immune system, often enough to eliminate it before an infection gains a foothold. Once an infection takes hold, it outbreeds the immune response as it’s the part best equipped to deal with a large viral load that it interferes with.
    • if you’ve got the virus in your body, but due to the lack of the receptor, it can’t reproduce, then it doesn’t remain viable for very long as each viron accumulates damage over time, and ceases to function once it’s too badly damaged. People carrying a disease have enough viral reproduction going on to balance out the virus being destroyed.


  • Even if you ignore that there’s an entirely valid sense of the word immune that has nothing do do with biology (i.e. the one in phrases like diplomatic immunity), my original comment is entirely consistent with the dictionary definition of the biological sense of the word. There are probably sub-fields of biology where immunity is used as jargon for something much more specific than the dictionary definition, but this is lemmyshitpost, not a peer-reviewed domain-specific publication.



  • When a normal person is exposed to HIV, it reproduces inside of them, so can then go on to expose more people, and if there’s enough of it, infect them in turn (if there’s a smaller amount, their immune system will normally be able to clean it up before it gets enough of a foothold). If someone’s lacking the receptor, then no matter how much they were exposed to, their immune system will eventually manage to remove it all without becoming infected because it can’t reproduce. If they had a ludicrously large viral load, then there’s a possibility that it could be passed on before it was destroyed, but most of the ways people get exposed to HIV aren’t enough to infect someone who’s vulnerable, let alone infect someone else via secondary exposure if there’s not been time for the infection to grow.


  • Usually, having to wrangle a junior developer takes a senior more time than doing the junior’s job themselves. The problem grows the more juniors they’re responsible for, so having LLMs stimulate a fleet of junior developers will be a massive time sink and not faster than doing everything themselves. With real juniors, though, this can still be worthwhile, as eventually they’ll learn, and then require much less supervision and become a net positive. LLMs do not learn once they’re deployed, though, so the only way they get better is if a cleverer model is created that can stimulate a mid-level developer, and so far, the diminishing returns of progressively larger and larger models makes it seem pretty likely that something based on LLMs won’t be enough.