You will also need to add PlayIntro=0 to the .ini file as well or the intro will crash the game. There’s one for playing at high resolutions as well and an audio dll to fix as well, but both of those are needed on Windows as well.

Edit: even then, the game crashes often in medium/late game. And the load game is a chore because it doesn’t store the last location. Overall it is a pain but I got through university this way playing on Ubuntu.