• Oizys@quokk.auEnglish
      8·
      1 day ago

      Alternatively: “wanna take a drag on my blunt?”, and just like that you’ll have someone who’ll be there whenever you need help to move a solid oak dresser.

      • ChickenLadyLovesLife@lemmy.worldEnglish
        4·
        24 hours ago

        I haven’t gotten high in more than five years. I miss the social aspect of it more than anything else. It’s what made disc golf such a great hobby.

              • JoeBigelow@lemmy.ca
                2·
                3 hours ago

                Main Reasons Doctors Avoid Diclofenac

                Cardiovascular Risks: Diclofenac increases the risk of serious heart attacks, strokes, heart failure, and blood clots at a rate comparable to specialized COX-2 inhibitors (like rofecoxib). Studies show these cardiovascular risks can begin within just 30 days of starting the medication, even at low doses.

                The People’s Pharmacy

                +4

                Gastrointestinal Complications: Like other NSAIDs, it blocks protective prostaglandins in the stomach, which can lead to severe ulcers and a 4.5-fold higher risk of gastrointestinal bleeding compared to non-users.

                Pulse Today

                +1

                Kidney and Liver Strain: It can reduce blood flow to the kidneys—causing acute kidney injury or worsening blood pressure—and has been linked to drug-induced liver damage.

                Safer Alternatives Exist: Other nonselective NSAIDs like naproxen or low-dose ibuprofen generally offer a more favorable cardiovascular and safety profile for long-term use. Guidance from organizations like the GOV.UK Drug Safety Update explicitly contraindicates systemic diclofenac for patients with established ischemic heart disease, peripheral arterial disease, or heart failure.

                nhs.uk

                +1

                Ok, whatever man.