I’m glad to hear that stuff like this is still going on. Nice!
Wow, this is really exciting. I guess it’ll take years more research before we’ll know if this can benefit humans, but if they can replicate the results with humans then it could potentially prevent chronic pain and mobility issues in millions of people.
Probably worth adding “in mice” to the title
Mice are really living in a golden age. They have never been so healthy.
And simultaneously unhealthy (otherwise how are we"curing" them)
And human tissues, and it’s been shown to be safe in phase I trials.
So saying “in mice” undersells where they are at.
This is not the xkcd I thought you were going to use
Which one did you have in mind?
This would be amazing for my wife. I mean I guess it would have been amazing if she still had her original knee. Maybe it’ll be amazing for the other knee one day.
Good. Biological aging is nothing more than a series of processes, not an inherent property of atoms, and it’s time we start getting serious about anti-aging and life extension.
But probably not, seeing what the world is like.
Is it though? The only time progress happens is when people die.
Only the rich will benefit.
People have been seeking life extension for all of recorded history.
Its mostly billionaires who will be able to benefit from life extension… do you really want a world where trump, musk, and all their silicon valley friends rule the world until they turn 300 years old?
No worries about that, there is no changing the maximum age seemingly, not unless you genetically engineered babies with tech we don’t have yet.
Everyone is born with stem cells that carry so many copies of cells that are preprogrammed to die after a point to then be replaced by those stem cells. No drug can make more copies after the fact.
Then of course the dna gets denatured just by radiation and pollution and time.
Neither of these will or can be solved after someone is born. They can extend the average lifespan of a group, but they can’t exceed the maximum, which has remained constant throughout human history even as the average has changed drastically.
What’s the maximum? About 120?
Imagine having 100 or more healthy years. That seems like sci-fi, but may be possible one day still.
It will also mean working until you’re 100 before the national pension kicks in unfortunately lol
Luckily there’s no vaccine against guillotines.
Give it time.
Aroooooo
Billionaires, and everybody living outside the US
So essentially Altered Carbon?
I think that’s more kinda digitised, transferable consciousness. I’d take it tho.
deleted by creator
Why do you think that? We already benefit from life extension. And why only 300?
“I plan to live forever, of course, but barring that I’d settle for a couple thousand years. Even five hundred would be pretty nice.”
CEO Nwabudike Morgan, “Sid Meier’s Alpha Centauri” (1999)
If you’re that worried, start working towards killing them. Seems like it’s going to be necessary step either way to correct many problems in the world. What’s one more reason for the pyre?
How about not life extension but quality of life extension instead (e.g. this post)
Indeed, I don’t really feel like living for more more than 90 years, I just want to be able to do what I like to do until I die.
I didn’t realize people weren’t being serious about it this whole time. The tens of millions of dollars of research grants seemed pretty serious.
LOL that pays for a focus group for branding. You can’t be serious.
You’re telling me you’re a “huge nerd,” but think medical research is done by companies and involves focus groups? Like, it’s a Marvel or something?
Jfc. If 90 million dollars isn’t anything to you, howbout you give yours away then bud.
Yes, medicine is marketed. Are you for real? Like, is there still amniotic fluid behind your ears? Great Hatching Day fellow creature! Welcome to Earth!
My joke was that tens of millions of dollars to research aging barely covers the test tubes. JFC.
Bud, they don’t market for a treatment before there’s even research conducted. How the fuck are you acting like you think giant research grants are not effort? Give me ten million dollars if it isn’t much then.
Americans, we get it, you have no healthcare system worth the name. Stop assuming nobody else worldwide can get the meds either.
Or maybe you could show a little sympathy once in a while
America did this shit to itself
And the civilised world gets dragged into the bullshit
And before you whine, the majority of Americans are a part of the problem in one way or another
Your society (for want of a better term) has gotten what it collectively wants
You try running into comments thinking they’re the only nation on earth in every health article and see how long you stay sympathetic.
Exactly. Functional public health systems will assess patient outcomes and the expenditure in money and resources to determine what treatments get approved.
The odds are pretty good that - if this works out - this will be on the list of approved treatments straight away. Surgery is an expensive and high-load pathway for public health systems. A non-surgical treatment that gives good outcomes is such a win-win for both patients and public health systems that it almost doesn’t matter how much it costs.
Sorry, is this not meant to sound like you’re a Eurocentrist douchebag? Medical care and resources are already not distributed proportionately throughout the world exactly because a small number of nations benefit from a brutally extractive colonial system that requires the dehumanization of other groups to exist.
The US doesn’t have a fucking healthcare system because it is a settler-colonial, imperialist military power that holds up the capitalist system that Europeans are such proud benefactors of. They violently enforce a system that inflicts as much precarity and vulnerability as possible on its people because it depends on preventing as many unprivileged people as possible from gaining enough resources to muster an effective challenge to its power within the metropole while maintaining its legitimacy to its more privileged working classes.
So, what the fuck are you bitching about? Americans saying that people won’t be able to afford it? They’re correct, most people will not have access to it so that fucks like you can thanks to the US guarding the loot. Fuck’s sake with you people.
Edit: Before any Euros try to bitch and whine about how unfair it is that you’re still colonizers, I do not care. I don’t fucking care. We are not going to do this thing where you can bitch about the US and pretend like you aren’t world destroyers for the same exact fucking reason it is. If you are not critical of how many EU and European settler nations have the wealth to sustain a healthcare system and quality of life that makes access to medicine an entitlement instead of a privilege, you’re not a serious person.
Australian here
Fuck off with your whining
You idiots did this to yourselves, ironically as a collective, because of your worship of the individual over society
Suck it, yank.
Says the guy that just let the trojan horse of age controls behind the walls of their liberal democracy. Get off your high horse mate, it’s time for your colonoscopy to prove you can use the internet so they can craft your social score off of all your information on half baked palantir ai models. Oi oi oi!
Not USAmerican. I’m willing to bet your colonizing ass doesn’t even know about Australia, look up Patrick Wolfe.
I’m Asian. My country was colonised by Europeans till half a century ago.
Keep going, this is funny. We’ve gone from ‘America is the only nation on earth’ to ‘oh yeah, Europe exists too’.
I’m Eastern European, my country was exploited by USSR until less than 40 years ago. My bad for getting excited about the prospect of being able to walk in old age, it’s all my fault for -checks notes- joining a freedom of trade and movement organisation
You imperialist coloniser superpower douchebag!
my country was exploited by USSR
Do you have a source for that? The inefficiencies of Communism and the lack of cheap third world resources is not the same as being colonised or post-colonised like a third world country.
Not necessarily what you’re looking for, but provides some interesting context for others
Why not? It shows that the USSR was doing the opposite.
However, especially by the end, the USSR was effectively paying to keep satellites afloat.
The first comment mentions as exploitation the dismantled production lines from East Germany. Counting war reparations as exploitation is not a honest argument.
The author shifts the tone latet-on.
I’m not entering the exploitation olympics here, feel free to disregard my argument if Eastern Europe doesn’t clear the suffering threshold in your book.
Reread the comment.
Maybe orioler25 will figure out that there’s more to the world than only the US and EU :D
Reread the comment and tell yourself that a criticism of EuroAmerican global imperialism is without consideration of colonized peoples. This history happened, sorry it compromises whatever power fantasy you have.
Doubtful
Waaah they called out my US defaultist ass and now I need to crash out that the Euros built functioning societies waaaaaaaah
Hey, how’d they build those “functioning” societies? Got a source? Extra points if you can even cite a decolonial history written by an indigenous person.
Nice little extra ableism in your comment too, like a good colonizer chud would say.
Reeeee anything I don’t like is brutal colonialism! Those damn Irish colonising Ireland! Don’t get me started on the fucking Icelanders! Reeeeeee
You’re saying you think it makes you sound smart to suspend your object permanence. Guess a capitalist system with so much wealth concentrated in the EU just happened, it’s just like that. If you want to be in the Colonial League of Doom, every single individual in your country must personally be a rubber baron. Otherwise, you’re valour stealing bastards, actually free from colonialism completely, and a hysterical blue haired SJW.
I seriously don’t know how you could type this shit and still respect yourself.
The Irish are famously perpetrators and beneficiaries of colonialism
I remember when I was a senior in high school back in the late 90s, my biology teacher mused one day that ours might be the first generation to not die of old age. I don’t know if I’m anywhere near as optimistic now as he was then, but it is incredibly exciting to think about. There have been a slew of discoveries over the past 20 years that have been building towards this, and it’s all been very fascinating. No idea if this is the grail or not, but it certainly seems like an important piece of the puzzle.
What exactly is exciting about making genocidal maniacs practically immortal?
my biology teacher mused one day that ours might be the first generation to not die of old age.
Good for you that it was not the history teacher.
not dying of old age is a stretch. probably not dying young of certain diseases has improved.
This and then the new about regrowing teeth. Its a very exciting time in medicine.
If you think anyone but the elite will be able to afford or procure these procedures, you’re incredibly optimistic.
As soon as it gets approved, some shitty corporation will purchase the patent and lock it behind a paywall for 80+ year old geriatrics with zero fucks given towards people who actually deserve or need it.
“Everything sucks.”
Boring.
So… anywhere but the USA it will be affordable(ie free) anyways? Okay.
Bremonia will have the procedures, for free. The name can be changed, I don’t care. I just need help overthrowing a few corrupt governments and I’m out.
This drug can be delivered via pill. It has a range of effects in reversing age related damage.
I’m not sure if it will be kept to the rich, or given out widely to justify the removal of social security, or at least jacking up the retirement age.
Maybe, but if PGE2 signaling is disrupted in non-cartilage tissues, it could promote abnormal growth or inflammation. For example, PGE2 has complex roles in cancer and fibrosis. And if the drug isn’t perfectly specific, it might inhibit other enzymes or pathways. This is because 15-PGDH is active in other tissues (e.g., liver, muscle, bone). Inhibiting it systemically might affect these tissues, though the study suggests localized joint injection could minimize this I suppose…
If the worker-slaves live longer, you don’t have to indoctrinate & capture new ones quite as often!
I’d like my partners knees to work again so they can do the things they like as they age, like riding bikes or hiking.
Lol Yankee problems
I’m not a Yankee, but thanks for assuming
You’re an American, that’s what Yankee means to everybody outside the states.
Are you seriously also down here saying racist shit to a Native American so that you can roleplay some flex on what you thought was just some poor USAmerican who couldn’t afford healthcare? Your good guy scenario was dunking on a poor person in an authoritarian state?
Europeans are seriously the most bloodthirsty fucks I’ll see online, and they’re predictably the most smug about it too.
I have no idea what you’re trying to say. Are you saying he’s NOT an American because he’s indigenous? And wtf is racist? At least now I know what his comment means. You people think everybody knows the same things you do.
(I’m Asian BTW, but yeah go on)
Oh but how dare you be Asian when you were already assigned European at post /s
“It isn’t racist to call a Native American a ‘yank’ because I’m ignorant about racism.” You’re telling me that you moderate a Norwegian community, talk a shit ton about Euro nations, but you think it doesn’t make you look like a racist asshole to not know what is racist about trying to dunk on an indigenous person (who, again, you thought was just some other poor person) by calling them a term that identifies them with the occupying settler state that has committed genocide against their people.
Yeah dude, totally not a bloodthirsty chud.
What do Europeans have to do with this?
Oh right, US-ians think any first-world country must be in Europe…
I’m old school American
#landback!!!
When they compared cartilage from young and old mice, they found that levels of 15-PGDH approximately doubled with age. To test the idea, researchers treated older mice with a small molecule drug that blocks 15-PGDH activity. [And cartilage regrew.]
Sounds very promising! I couldn’t figure out the peer-reviewed-ness status.
Yeah but while PGE2 promotes cartilage repair, it also plays roles in inflammation, fever, and gastrointestinal issues. If PGE2 levels rise too high or in the wrong context, it could cause unwanted inflammation or side effects similar to NSAIDs (e.g. stomach irritation).
I think I’d be okay with some stomach irritation to regain use of my knees in my old age.
in mice though, since none of these recent one works in humans yet.
Ready for someone to tell me why this unfortunately won’t work / become mainstream
Well, this same drug (working name MF-300) is a PDGH-15 inhibitor and has already been through phase 1 human trials for a separate condition.
Because PDGH-15 also causes age related muscle weakness.
Now, PDGH-15 also plays a role in cancer prevention, and there may be a few other less obvious functions.
I don’t know if the results of the phase 1 trials have been published yet, but it’s been a while since I checked.
I’ve been hearing about MF-300 for a little under a year, and with these same claims about restoring cartilage.
Money, usually. Or cancer. God i sound depressing 😄
Money cancer.
Ah, the billionaires again.
Finally some good fucking news.
I’m in this thumbnail and I want that right now.
Just in time for me to get old!
Wrong end of the stick, as usual
Amazing!
